Persönlicher Status und Werkzeuge

AG Oliver Lange - Computational Structural Biology

We are interested in understanding the basic principles that govern conformational motion to enable a rational modulation of dynamic behavior of engineered biomolecules such as artificial enzymes and inhibitors.

As a stepping stone we strive to rationally design simple model systems that undergo specific conformational changes. To detect and characterize conformational changes we use Nuclear Magnetic Resonance (NMR) Spectroscopy. We will also continue our effort to develop computational tools to determine structure and dynamics of proteins with the help of sparse NMR data

We are associated with the groups of Prof. Michael Sattler and Prof. Bernd Reif. The group is integrated into the Bavarian NMR Center, and associated with the Institute of Structural Biology at the Helmholtz-Zentrum München

The 25kDa protein Alg13 determined from sparse NMR data with CS-Rosetta